apalutamide will reduce the extent or result of ethinylestradiol by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Prevent or Use Alternate Drug. Coadministration of apalutamide, a robust CYP3A4 inducer, with medication which can be CYP3A4 substrates can lead to lower exposure to those medications.Women of all ages who now have or have ex